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Poziotinib hydrochloride

CAS No. 1429757-68-5

Poziotinib hydrochloride ( NOV120101 hydrochloride,HM 781-36B hydrochloride )

Catalog No. M22736 CAS No. 1429757-68-5

Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors.?It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 68 In Stock
25MG 115 In Stock
50MG 173 In Stock
100MG 258 In Stock
200MG 388 In Stock
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Biological Information

  • Product Name
    Poziotinib hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors.?It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.?
  • Description
    Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors.?It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.?
  • Synonyms
    NOV120101 hydrochloride,HM 781-36B hydrochloride
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR
  • Research Area
    Cancer
  • Indication
    Breast Cancer; Gastric Cancer; Head and neck Cancer; Lung Cancer; Non-small cell lung Cancer

Chemical Information

  • CAS Number
    1429757-68-5
  • Formula Weight
    527.8
  • Molecular Formula
    C23H22Cl3FN4O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.COc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3F)c2cc1OC1CCN(CC1)C(=O)C=C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nam HJ, et al. Cancer Lett. 2011, 302(2), 155-165.
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